Time is of the essence when one competes to purify less than a gram of protein or peptide to file for a patent and then move towards preclinical trials, or even gram and kilogram quantities for Phase II and III clinical trials. You need a fast, efficient media to provide you with non-contaminated final product.
High capacity, high flow rate, high pressure and chemical tolerance, clean in place option, as well as the unique mechanical stability of STYROS® and StyrosZyme® provides the perfect candidate for continuous separation processes such as Simulated Moving Bed Chromatography. The limitations imposed by column size in large scale bio-processing can be overcome by the use of such stationary phases while at the same time reducing the overall size of the manufacturing facility. STYROS® and StyrosZyme® media are fully pervious poly (styrene-divinylbenzene) matrices manufactured by OraChrom. The unique properties of STYROS® and StyrosZyme® have been recognized by some of the most reputable biopharmaceutical manufacturers and have included it in their FDA approved production.
The Full Range of Simulated Monolith™, Non Leaching Hard Gel Polymer-based HPLC Columns for High Speed, High Resolution Chromatography with New Lines of Micro Trap Columns as well as Fused Silica Capillary Columns. From Micro Trap columns of 1 nl of column volume to normal bore of 88.2 ml of column volume.
Simple description of Simulated Moving Bed chromatography
A brief history of Liquid Chromatography including its major types